ARSENIC TRIOXIDE
MSDS Number: A7512 --- Effective Date: 08/02/00
1. Product Identification
Synonyms: Arsenic (III) oxide; arsenic sesquioxide; arsenous
trioxide, white arsenic
CAS No.: 1327-53-3
Molecular Weight: 197.84
Chemical Formula: As2O3
Product Codes: 0061
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
Arsenic Trioxide 1327-53-3 99 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! MAY BE FATAL IF SWALLOWED OR INHALED. CANCER HAZARD. CONTAINS
INORGANIC ARSENIC WHICH CAN CAUSE CANCER. Risk of cancer depends on
duration and level of exposure. CAUSES IRRITATION TO SKIN, EYES AND
RESPIRATORY TRACT. MAY CAUSE LIVER AND KIDNEY DAMAGE. USE ONLY WITH
ADEQUATE VENTILATION AND RESPIRATORY EQUIPMENT.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 4 - Extreme (Cancer Causing)
Flammability Rating: 0 - None
Reactivity Rating: 1 - Slight
Contact Rating: 1 - Slight
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Blue (Health)
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Potential Health Effects
----------------------------------
Inhalation:
Arsenic may cause inflammation of the mucous membranes with cough and foamy
sputum, restlessness, dyspnea, cyanosis, and rales. Symptoms like those
from ingestion exposure may follow. May cause pulmonary edema.
Ingestion:
Arsenic is highly toxic! May cause burning in esophagus, vomiting, and
bloody diarrhea. Symptoms of cold and clammy skin, low blood pressure,
weakness, headache, cramps, convulsions, and coma may follow. May cause
damage to liver and kidneys. A suspected fetal toxin. Death may occur from
circulatory failure. Estimated lethal dose 120 milligrams.
Skin Contact:
May cause irritation, symptoms including redness, itching, and pain.
Eye Contact:
May cause irritation with itching, burning, watering of eyes; may cause
conjunctiva damage.
Chronic Exposure:
Arsenic on repeated or prolonged skin contact may cause bronzing of the
skin, edema, dermatitis, and lesions. Repeated or prolonged inhalation of
dust may cause damage to the nasal septum. Chronic exposure from inhalation
or ingestion may cause hair and weight loss, a garlic odor to the breath
and perspiration, excessive salivation and perspiration, central nervous
system damage, hepatitis, gastrointestinal disturbances, cardiovascular
damage, and kidney and liver damage. Arsenic compounds are known human
carcinogens and may be teratogenic based on effects in laboratory animals.
Aggravation of Pre-existing Conditions:
No information found.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give
anything by mouth to an unconscious person. Get medical attention
immediately.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical attention
immediately. Wash clothing before reuse. Thoroughly clean shoes before
reuse. Contaminated work clothes should be laundered by individuals who
have been informed of the hazards of exposure to this substance.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes,
lifting lower and upper eyelids occasionally. Get medical attention
immediately.
Note to Physician:
If emesis if unsuccessful after two doses of Ipecac, consider gastric
lavage. Monitor urine arsenic level. Alkalization of urine may help
prevent disposition of red cell breakdown products in renal tubular cells.
If acute exposure is significant, maintain high urine output and monitor
volume status, preferably with central venous pressure line. Abdominal
X-rays should be done routinely for all ingestions. Chelation therapy with
BAL, followed by n-penicillamine is recommended, but specific dosing
guidelines are not clearly established.
5. Fire Fighting Measures
Fire:
Not considered to be a fire hazard. Toxic fumes of arsenic trioxide and arsine may be formed in fire situations.
Explosion:
Not considered to be an explosion hazard.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode.
6. Accidental Release Measures
Ventilate area of leak or spill. Wear appropriate personal protective
equipment as specified in Section 8. Spills: Sweep up and containerize for
reclamation or disposal. Vacuuming or wet sweeping may be used to avoid
dust dispersal. US Regulations (CERCLA) require reporting spills and
releases to soil, water and air in excess of reportable quantities. The
toll free number for the US Coast Guard National Response Center is (800)
424-8802.
7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area.
Protect against physical damage. Isolate from incompatible substances. Wear
special protective equipment (Sec. 8) for maintenance break-in or where
exposures may exceed established exposure levels. Wash hands, face,
forearms and neck when exiting restricted areas. Shower, dispose of outer
clothing, change to clean garments at the end of the day. Avoid
cross-contamination of street clothes. Wash hands before eating and do not
eat, drink, or smoke in workplace. Containers of this material may be
hazardous when empty since they retain product residues (dust, solids);
observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
10 ug(As)/m3 ppm (TWA)
-ACGIH Threshold Limit Value (TLV):
0.01 mg(As)/m3 (TWA),
listed as A1, confirmed human carcinogen.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne Exposure Limits. Local exhaust ventilation is
generally preferred because it can control the emissions of the contaminant
at its source, preventing dispersion of it into the general work area.
Please refer to the ACGIH document, Industrial Ventilation, A Manual of
Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face high efficiency dust/mist
respirator may be worn for up to ten times the exposure limit or the
maximum use concentration specified by the appropriate regulatory agency or
respirator supplier, whichever is lowest. A full-face piece high
efficiency dust/mist respirator may be worn up to 50 times the exposure
limit, or the maximum use concentration specified by the appropriate
regulatory agency or respirator supplier, whichever is lowest. For
emergencies or instances where the exposure levels are not known, use a
full-facepiece positive-pressure, air-supplied respirator. WARNING:
Air-purifying respirators do not protect workers in oxygen-deficient
atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat,
apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or
splashing of solutions is possible. Maintain eye wash fountain and
quick-drench facilities in work area.
Other Control Measures:
Any area where inorganic arsenic is stored, handled, used, etc., must be
established as a 'Regulated Area' with controlled access, limited to
authorized persons. Containers of inorganic arsenic and Regulated Areas
must be labeled to show a CANCER SUSPECT AGENT is present.
Eating, drinking, and smoking should not be permitted in areas where solids
or liquids containing arsenic or lead compounds are handled, processed, or
stored.
See OSHA substance-specific standard for more information on personal
protective equipment, engineering and work practice controls, medical
surveillance, record keeping, and reporting requirements. (arsenic: 29 CFR
1910 .1018; lead: 29 CFR 1910.1025).
9. Physical and Chemical Properties
Appearance:
Transparent crystals, or white powder.
Odor:
Odorless.
Solubility:
3.7 g/l00 ml water @ 20C (68F)
Specific Gravity:
3.74
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
465C (869F)
Melting Point:
315C (599F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Emits toxic fumes of arsenic when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Oxidizers, tannic acid, infusion cinchona and other vegetable astringent
infusions and decoctions, iron solutions, rubidium carbide, chlorine
trifluoride, fluorine, hydrogen fluoride, oxygen difluoride, acids, bases,
sodium chlorate, zinc filings, other reactive metals and mercury. Corrosive
to metals in the presence of moisture.
Conditions to Avoid:
Incompatibles.
11. Toxicological Information
Toxicological Data:
Oral rat LD50: 14.6 mg/kg; investigated as a mutagen, tumorigen,
reproductive effector.
Reproductive Toxicity:
Has shown teratogenic effects in laboratory animals.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
Arsenic Trioxide (1327-53-3) Yes No 1
12. Ecological Information
Environmental Fate:
When released into the soil, this material may biodegrade to a moderate
extent. When released into water, this material may biodegrade to a
moderate extent. This material is not expected to significantly
bioaccumulate.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved waste facility. Processing, use
or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations.
Dispose of container and unused contents in accordance with federal, state
and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: RQ, ARSENIC TRIOXIDE
Hazard Class: 6.1
UN/NA: UN1561
Packing Group: II
Information reported for product/size: 500G
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN/NA: UN1561
Packing Group: II
Information reported for product/size: 500G
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN/NA: UN1561
Packing Group: II
Information reported for product/size: 500G
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
Arsenic Trioxide (1327-53-3) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
Arsenic Trioxide (1327-53-3) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
Arsenic Trioxide (1327-53-3) 1 100* No Arsenic comp
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
Arsenic Trioxide (1327-53-3) 1 P012 No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: No (Pure / Solid)
WARNING:
THIS PRODUCT CONTAINS CHEMICALS KNOWN TO THE STATE OF CALIFORNIA
TO CAUSE CANCER AND BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.
Australian Hazchem Code: 2Z
Poison Schedule: S6
WHMIS:
This MSDS has been prepared according to the hazard criteria of
the Controlled Products Regulations (CPR) and the MSDS contains
all of the information required by the CPR.
16. Other Information
NFPA Ratings:
Health: 3 Flammability: 0 Reactivity: 0
Label Hazard Warning:
DANGER! MAY BE FATAL IF SWALLOWED OR INHALED. CANCER HAZARD. CONTAINS
INORGANIC ARSENIC WHICH CAN CAUSE CANCER. Risk of cancer depends on duration
and level of exposure. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT.
MAY CAUSE LIVER AND KIDNEY DAMAGE. USE ONLY WITH ADEQUATE VENTILATION AND
RESPIRATORY EQUIPMENT.
Label Precautions:
Do not get in eyes, on skin, or on clothing.
Do not breathe dust.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel.
Never give anything by mouth to an unconscious person. Get medical attention
immediately. If inhaled, remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case of
contact, immediately flush eyes or skin with plenty of water for at least 15
minutes. Remove contaminated clothing and shoes. Wash clothing before
reuse. In all cases, get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:
No changes.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or accuracy.
This document is intended only as a guide to the appropriate precautionary
handling of the material by a properly trained person using this product.
Individuals receiving the information must exercise their independent judgment
in determining its appropriateness for a particular purpose. MALLINCKRODT
BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)